551-560-Peng GongR

نویسندگان

  • Peng Gong
  • Haibo Xu
  • Jianing Zhang
  • Zhongyu Wang
چکیده

Peroxisome-proliferator responsive element (PPRE) and nuclear factor-κB (NF-κB) response element have been found in the gene sequence of superoxide dismutase (SOD). This study determines the PPARs and NF-κB expression and SOD activity in damaged livers of rats with obstructive jaundice. Sprague-Dawley rats (n = 120) were randomly assigned into four groups: sham 7 days post-surgery (Sham 7), bile duct ligation (BDL) 7 days post-surgery (BDL 7), sham 19 days post-surgery (Sham 19), BDL 19 days post-surgery (BDL 19). Rats were sacrificed and blood samples and liver tissue were preserved at 7 days and 19 days postsurgery. SOD enzyme activity was detected by a commercially available kit. PPAR mRNA expression was determined by RT-PCR. PPAR protein expression and NF-κB expression and activation were determined by immunohistochemistry. Student’s t-test and Pearson correlation were employed using SPSS statistical software. Total SOD and Cu/Zn-SOD activity was decreased in the BDL groups compared with the sham group (P < 0.01). PPARs mRNA and protein expressions in the BDL groups liver were also reduced compared with the sham group (P < 0.01). Both SOD and Cu/Zn-SOD activity and PPAR expression was significantly decreased between the BDL 7 and BDL 19 groups. PPAR protein expression positively correlated with total SOD activity (P < 0.01), and negatively correlated with NF-κB p65 protein expression in the rats (P < 0.01). PPARs may play a role in liver damage in rats with obstructive jaundice through regulation of SOD and NF-κB gene expression.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Equity by the Numbers: Measuring Poverty, Inequality, and Injustice

INTRODUCTION .......................................................................................... 551 I. EQUITY METRICS: AN OVERVIEW .......................................................... 559 A. Inequality Metrics .................................................................... 560 B. Social Welfare Functions ......................................................... 566 C. Poverty...

متن کامل

Cytochromes of aquatic fungi.

The cytochrome systems of two classes of aquatic fungi, the Oomycetes and Chytridiomycetes, were studied by means of reduced-minus-oxidized difference spectra at room and at low temperature. At room temperature, all of these fungi have a c-type cytochrome with an absorption maximum at 551 mmu and a b-type cytochrome at 564 mmu. The Oomycetes have a-type cytochromes at 605 mmu, and the Chytridio...

متن کامل

Legal Networks: the Promises and Challenges of Legal Network Analysis

INTRODUCTION ............................................................................... 539 I. NETWORK ANALYSIS BACKGROUND ...................................... 540 A. What is a Network? ......................................................... 541 B. Network Analysis History ............................................... 543 1. Social Network Analysis ......................................

متن کامل

Learning from Corrupted Binary Labels via Class- Probability Estimation Classification with Corrupted Binary Labels

550 551 552 553 554 555 556 557 558 559 560 561 562 563 564 565 566 567 568 569 570 571 572 573 574 575 576 577 578 579 580 581 582 583 584 585 586 587 588 589 590 591 592 593 594 595 596 597 598 599 600 601 602 603 604 605 606 607 608 609 610 611 612 613 614 615 616 617 618 619 620 621 622 623 624 625 626 627 628 629 630 631 632 633 634 635 636 637 638 639 640 641 642 643 644 645 646 647 648 6...

متن کامل

Preparation of Pt Ag alloy nanoisland/graphene hybrid composites and its high stability and catalytic activity in methanol electro-oxidation

In this article, PtAg alloy nanoislands/graphene hybrid composites were prepared based on the self-organization of Au@PtAg nanorods on graphene sheets. Graphite oxides (GO) were prepared and separated to individual sheets using Hummer's method. Graphene nano-sheets were prepared by chemical reduction with hydrazine. The prepared PtAg alloy nanomaterial and the hybrid composites with graphene we...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2012